Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
Q92743

Serine protease HTRA1 (Q92743)

Uniprot ID Q92743
Protein Name Serine protease HTRA1
Gene Name HTRA1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.681
Function Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. .
GO - Molecular function
  • identical protein binding : IPI:IntAct
  • insulin-like growth factor binding : IEA:InterPro
  • serine-type endopeptidase activity : TAS:ProtInc
  • serine-type peptidase activity : ISS:UniProtKB
GO - Biological process
  • chorionic trophoblast cell differentiation : IEA:Ensembl
  • dentinogenesis : IEA:Ensembl
  • extracellular matrix disassembly : TAS:Reactome
  • negative regulation of BMP signaling pathway : IEA:Ensembl
  • negative regulation of defense response to virus : IEA:Ensembl
  • negative regulation of transforming growth factor beta receptor signaling pathway : IEA:Ensembl
  • placenta development : IEA:Ensembl
  • positive regulation of epithelial cell proliferation : IEA:Ensembl
  • proteolysis : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.