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Q92692

Nectin-2 (Q92692)

Uniprot ID Q92692
Protein Name Nectin-2
Gene Name NECTIN2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.213
Function Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705). Probable cell adhesion protein (PubMed:9657005). .(Microbial infection) Acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). {ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:9657005}.
GO - Molecular function
  • cell adhesion molecule binding : IPI:BHF-UCL
  • coreceptor activity : TAS:ProtInc
  • identical protein binding : IPI:IntAct
  • protein homodimerization activity : IPI:BHF-UCL
  • virus receptor activity : IEA:UniProtKB-KW
GO - Biological process
  • acrosome assembly : IEA:Ensembl
  • adherens junction organization : TAS:Reactome
  • adhesion of symbiont to host : IDA:BHF-UCL
  • cell part morphogenesis : IEA:Ensembl
  • cilium organization : IEA:Ensembl
  • coreceptor-mediated virion attachment to host cell : IDA:BHF-UCL
  • cytoskeleton organization : IEA:Ensembl
  • establishment of mitochondrion localization : IEA:Ensembl
  • fertilization : IEA:Ensembl
  • fusion of virus membrane with host plasma membrane : IDA:BHF-UCL
  • homophilic cell adhesion via plasma membrane adhesion molecules : IDA:BHF-UCL
  • positive regulation of immunoglobulin mediated immune response : IMP:BHF-UCL
  • positive regulation of mast cell activation : IMP:BHF-UCL
  • positive regulation of natural killer cell mediated cytotoxicity : IMP:BHF-UCL
  • positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target : IMP:BHF-UCL
  • positive regulation of T cell receptor signaling pathway : IDA:UniProtKB
  • regulation of immune response : TAS:Reactome
  • regulation of viral entry into host cell : IDA:CACAO
  • sperm mitochondrion organization : IEA:Ensembl
  • spermatid development : ISS:BHF-UCL
  • spermatid nucleus differentiation : IEA:Ensembl
  • susceptibility to natural killer cell mediated cytotoxicity : IMP:BHF-UCL
  • susceptibility to T cell mediated cytotoxicity : IDA:BHF-UCL
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.