Sodium/hydrogen exchanger 6 (Q92581)

Uniprot ID Q92581
Protein Name Sodium/hydrogen exchanger 6
Gene Name SLC9A6
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.09
Function Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.
GO - Molecular function
  • potassium : IBA:GO_Central
  • sodium : IBA:GO_Central
GO - Biological process
  • axon extension : IDA:MGI
  • brain-derived neurotrophic factor receptor signaling pathway : IEA:Ensembl
  • dendrite extension : IDA:MGI
  • dendritic spine development : IEA:Ensembl
  • ion transport : TAS:Reactome
  • neuron projection morphogenesis : IDA:MGI
  • potassium ion transmembrane transport : IBA:GO_Central
  • regulation of intracellular pH : IBA:GO_Central
  • regulation of neurotrophin TRK receptor signaling pathway : IEA:Ensembl
  • sodium ion import across plasma membrane : IBA:GO_Central
  • synapse organization : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.