Ras-related protein Rab-14 (Q91V41)

Uniprot ID Q91V41
Protein Name Ras-related protein Rab-14
Gene Name Rab14
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.686
Function Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). .
GO - Molecular function
  • GDP binding : ISS:UniProtKB
  • GTP binding : ISS:UniProtKB
  • GTPase activity : ISS:UniProtKB
  • myosin V binding : ISO:MGI
GO - Biological process
  • apical protein localization : ISO:MGI
  • body fluid secretion : ISO:MGI
  • defense response to bacterium : IEA:InterPro
  • embryo development : IMP:UniProtKB
  • endocytic recycling : ISS:UniProtKB
  • fibroblast growth factor receptor signaling pathway : IMP:UniProtKB
  • Golgi to endosome transport : IMP:UniProtKB
  • phagosome maturation : IEA:InterPro
  • protein transport : IEA:UniProtKB-KW
  • regulation of endocytosis : IBA:GO_Central
  • regulation of protein localization : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.