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Q8WXS8

A disintegrin and metalloproteinase with thrombospondin motifs 14 (Q8WXS8)

Uniprot ID Q8WXS8
Protein Name A disintegrin and metalloproteinase with thrombospondin motifs 14
Gene Name ADAMTS14
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.53
Function Has aminoprocollagen type I processing activity in the absence of ADAMTS2 (PubMed:11741898). Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity (PubMed:11741898). Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form (PubMed:31152061). .
GO - Molecular function
  • metal ion binding : IEA:UniProtKB-KW
  • metalloendopeptidase activity : IEA:InterPro
GO - Biological process
  • collagen catabolic process : IEA:UniProtKB-KW
  • collagen fibril organization : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.