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Q8WVM8

Sec1 family domain-containing protein 1 (Q8WVM8)

Uniprot ID Q8WVM8
Protein Name Sec1 family domain-containing protein 1
Gene Name SCFD1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.567
Function Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with COG4. Involved in vesicular transport between the endoplasmic reticulum and the Golgi (By similarity). .
GO - Molecular function
  • protein N-terminus binding : IEA:Ensembl
  • syntaxin binding : ISS:UniProtKB
GO - Biological process
  • cell morphogenesis : ISS:ParkinsonsUK-UCL
  • COPII vesicle coating : TAS:Reactome
  • negative regulation of autophagosome assembly : IMP:UniProtKB
  • post-Golgi vesicle-mediated transport : ISS:UniProtKB
  • protein transport : IEA:UniProtKB-KW
  • regulation of ER to Golgi vesicle-mediated transport : ISS:UniProtKB
  • regulation of protein transport : IMP:UniProtKB
  • response to hypoxia : IEA:Ensembl
  • response to toxic substance : IEP:UniProtKB
  • retrograde vesicle-mediated transport, Golgi to ER : ISS:UniProtKB
  • toxin transport : IEA:Ensembl
  • vesicle docking involved in exocytosis : IEA:InterPro
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.