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Q8R4Y4

Stabilin-1 (Q8R4Y4)

Uniprot ID Q8R4Y4
Protein Name Stabilin-1
Gene Name Stab1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.0
Function Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system (By similarity). .
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • hyaluronic acid binding : IEA:InterPro
  • low-density lipoprotein particle binding : ISS:UniProtKB
  • low-density lipoprotein particle receptor activity : ISS:UniProtKB
  • scavenger receptor activity : ISS:UniProtKB
GO - Biological process
  • cell adhesion : IEA:InterPro
  • cell-cell signaling : ISS:UniProtKB
  • defense response to bacterium : ISS:UniProtKB
  • inflammatory response : IEA:UniProtKB-KW
  • negative regulation of angiogenesis : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.