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Q8R2Z0

Adipolin (Q8R2Z0)

Uniprot ID Q8R2Z0
Protein Name Adipolin
Gene Name C1qtnf12
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) Y Secretome P(b) 0.684
Function Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (PubMed:21849507, PubMed:22275362). .Adipolin fC1QTNF12: Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes (PubMed:22942287). {ECO:0000269|PubMed:22942287}.Adipolin gC1QTNF12: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes (PubMed:22942287). {ECO:0000269|PubMed:22942287}.
GO - Molecular function
  • hormone activity : IDA:UniProtKB
GO - Biological process
  • negative regulation of gluconeogenesis : IDA:MGI
  • negative regulation of inflammatory response : IDA:MGI
  • positive regulation of glucose import : IMP:MGI
  • positive regulation of insulin receptor signaling pathway : IDA:MGI
  • positive regulation of insulin secretion involved in cellular response to glucose stimulus : IDA:MGI
  • positive regulation of protein kinase B signaling : IDA:MGI
  • regulation of glucose import : IDA:UniProtKB
  • regulation of glucose metabolic process : IDA:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.