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Q8NFT8

Delta and Notch-like epidermal growth factor-related receptor (Q8NFT8)

Uniprot ID Q8NFT8
Protein Name Delta and Notch-like epidermal growth factor-related receptor
Gene Name DNER
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.43
Function Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis (By similarity). .
GO - Molecular function
  • calcium ion binding : NAS:UniProtKB
  • clathrin binding : TAS:UniProtKB
  • Notch binding : IBA:GO_Central
  • transmembrane signaling receptor activity : TAS:UniProtKB
GO - Biological process
  • central nervous system development : IEP:UniProtKB
  • endocytosis : NAS:UniProtKB
  • glial cell differentiation : IEA:Ensembl
  • neuron migration : NAS:UniProtKB
  • Notch receptor processing : IEA:Ensembl
  • Notch signaling pathway : IEA:UniProtKB-KW
  • skeletal muscle fiber development : IEA:Ensembl
  • synapse assembly : NAS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.