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Q8N8S7

Protein enabled homolog (Q8N8S7)

Uniprot ID Q8N8S7
Protein Name Protein enabled homolog
Gene Name ENAH
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.461
Function Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation (By similarity). .
GO - Molecular function
  • actin binding : IEA:UniProtKB-KW
  • SH3 domain binding : IEA:UniProtKB-KW
  • WW domain binding : IPI:UniProtKB
GO - Biological process
  • axon guidance : TAS:Reactome
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.