Protein shisa-5 (Q8N114)

Uniprot ID Q8N114
Protein Name Protein shisa-5
Gene Name SHISA5
Species Homo sapiens (Human)
Signal peptide(a) N Secretome P(b) 0.308
Function Can induce apoptosis in a caspase-dependent manner and plays a role in p53/TP53-dependent apoptosis. .
GO - Molecular function
  • WW domain binding : IPI:UniProtKB
GO - Biological process
  • cellular protein metabolic process : TAS:Reactome
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator : IEA:Ensembl
  • positive regulation of I-kappaB kinase/NF-kappaB signaling : HMP:UniProtKB
  • post-translational protein modification : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.