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Q8IX30

Signal peptide, CUB and EGF-like domain-containing protein 3 (Q8IX30)

Uniprot ID Q8IX30
Protein Name Signal peptide, CUB and EGF-like domain-containing protein 3
Gene Name SCUBE3
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.527
Function Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. .
GO - Molecular function
  • calcium ion binding : IEA:InterPro
GO - Biological process
  • cell differentiation : IBA:GO_Central
  • extracellular matrix disassembly : TAS:Reactome
  • positive regulation of smoothened signaling pathway : IEA:Ensembl
  • protein heterooligomerization : IPI:UniProtKB
  • protein homooligomerization : IDA:UniProtKB
  • signal transduction : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.