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Q8CIV8

Tubulin-specific chaperone E (Q8CIV8)

Uniprot ID Q8CIV8
Protein Name Tubulin-specific chaperone E
Gene Name Tbce
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (2) Interactions
Signal peptide(a) N Secretome P(b) 0.551
Function Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation (PubMed:12389029, PubMed:17184771). Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network (By similarity). .
GO - Molecular function
  • unfolded protein binding : TAS:MGI
GO - Biological process
  • adult locomotory behavior : IMP:MGI
  • axonogenesis : IMP:MGI
  • developmental growth : IMP:MGI
  • microtubule cytoskeleton organization : IMP:MGI
  • mitotic spindle organization : ISS:UniProtKB
  • muscle atrophy : IMP:MGI
  • peripheral nervous system neuron axonogenesis : IMP:MGI
  • post-chaperonin tubulin folding pathway : ISS:UniProtKB
  • post-embryonic development : IMP:MGI
  • protein folding : TAS:MGI
  • tubulin complex assembly : TAS:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.