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Q8CG19

Latent-transforming growth factor beta-binding protein 1 (Q8CG19)

Uniprot ID Q8CG19
Protein Name Latent-transforming growth factor beta-binding protein 1
Gene Name Ltbp1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) Y Secretome P(b) 0.491
Function May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extracellular matrix (ECM).
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • microfibril binding : ISO:MGI
  • transforming growth factor beta binding : ISO:MGI
GO - Biological process
  • aorta development : IMP:MGI
  • coronary vasculature development : IMP:MGI
  • positive regulation of collagen biosynthetic process : ISO:MGI
  • transforming growth factor beta receptor signaling pathway : TAS:MGI
  • ventricular septum development : IMP:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.