Complement C1s-A subcomponent (Q8CG14)

Uniprot ID Q8CG14
Protein Name Complement C1s-A subcomponent
Gene Name C1sa
Species Mus musculus (Mouse)
Signal peptide(a) Y Secretome P(b) 0.0
Function C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4 (By similarity). .
GO - Molecular function
  • calcium ion binding : IEA:InterPro
  • identical protein binding : ISO:MGI
  • serine-type endopeptidase activity : ISO:MGI
GO - Biological process
  • complement activation, classical pathway : IEA:UniProtKB-KW
  • complement activation, lectin pathway : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.