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Q8BU30

Isoleucine--tRNA ligase, cytoplasmic (Q8BU30)

Uniprot ID Q8BU30
Protein Name Isoleucine--tRNA ligase, cytoplasmic
Gene Name Iars
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) N Secretome P(b) 0.495
Function Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. .
GO - Molecular function
  • aminoacyl-tRNA editing activity : IEA:InterPro
  • ATP binding : IEA:UniProtKB-KW
  • GTPase binding : ISO:MGI
  • isoleucine-tRNA ligase activity : IMP:CAFA
  • tRNA binding : IEA:InterPro
GO - Biological process
  • isoleucyl-tRNA aminoacylation : IDA:CAFA
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.