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Q80YX1

Tenascin (Q80YX1)

Uniprot ID Q80YX1
Protein Name Tenascin
Gene Name Tnc
Species Mus musculus (Mouse)
Basic Information Experiments (5) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.48
Function Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins ITGA8:ITGB1, ITGA9:ITGB1, ITGAV:ITGB3 and ITGAV:ITGB6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (By similarity). .
GO - Molecular function
  • fibronectin binding : ISO:MGI
  • syndecan binding : ISO:MGI
GO - Biological process
  • bud outgrowth involved in lung branching : ISO:MGI
  • cell adhesion : IEA:UniProtKB-KW
  • cellular response to prostaglandin D stimulus : IEA:Ensembl
  • cellular response to retinoic acid : IEA:Ensembl
  • cellular response to vitamin D : IEA:Ensembl
  • mesenchymal-epithelial cell signaling involved in prostate gland development : IMP:MGI
  • negative regulation of cell adhesion : ISO:MGI
  • neuromuscular junction development : IMP:MGI
  • neuron projection development : ISO:MGI
  • odontogenesis of dentin-containing tooth : IEA:Ensembl
  • peripheral nervous system axon regeneration : IMP:MGI
  • positive regulation of cell proliferation : IDA:MGI
  • positive regulation of gene expression : IDA:MGI
  • prostate gland epithelium morphogenesis : IMP:MGI
  • response to ethanol : IEA:Ensembl
  • response to fibroblast growth factor : IEA:Ensembl
  • response to mechanical stimulus : IEA:Ensembl
  • wound healing : IEA:Ensembl
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.