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Q80X41

Serine/threonine-protein kinase VRK1 (Q80X41)

Uniprot ID Q80X41
Protein Name Serine/threonine-protein kinase VRK1
Gene Name Vrk1
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.505
Function Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity (By similarity). .
GO - Molecular function
  • ATP binding : IEA:UniProtKB-KW
  • histone kinase activity (H3-S10 specific) : ISO:MGI
  • histone kinase activity (H3-T3 specific) : ISO:MGI
  • nucleosomal histone binding : ISO:MGI
  • protein kinase activity : ISO:MGI
  • protein kinase binding : ISO:MGI
  • protein serine/threonine kinase activity : IDA:MGI
GO - Biological process
  • cell cycle : IEA:UniProtKB-KW
  • cell division : IEA:UniProtKB-KW
  • Golgi disassembly : ISS:UniProtKB
  • histone H3-S10 phosphorylation : ISO:MGI
  • histone H3-T3 phosphorylation : ISO:MGI
  • peptidyl-serine phosphorylation : IBA:GO_Central
  • protein autophosphorylation : IDA:MGI
  • protein phosphorylation : IDA:MGI
  • regulation of cell shape : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.