Destrin (Q7M0E3)

Uniprot ID	Q7M0E3
Protein Name	Destrin
Gene Name	Dstn
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	N	Secretome P^(b)
Function	Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner. .
GO - Molecular function	actin filament binding : ISS:UniProtKB
GO - Biological process	actin filament depolymerization : ISO:RGD actin filament fragmentation : ISO:RGD actin filament severing : IEA:InterPro positive regulation of actin filament depolymerization : ISO:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}