Astrocytic phosphoprotein PEA-15 (Q78ZC9)

Uniprot ID Q78ZC9
Protein Name Astrocytic phosphoprotein PEA-15
Gene Name Pea15
Species Rattus norvegicus (Rat)
Signal peptide(a) N Secretome P(b)
Function Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6-and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). .
GO - Molecular function
GO - Biological process
  • apoptotic process : IEA:UniProtKB-KW
  • carbohydrate transport : IEA:UniProtKB-KW
  • DNA damage checkpoint : IEA:InterPro
  • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:RGD
  • negative regulation of glucose import : ISO:RGD
  • positive regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:RGD
  • response to morphine : IEP:RGD
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.