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Q78ED4

Elongation factor 1-alpha 1 (Q78ED4)

Uniprot ID Q78ED4
Protein Name Elongation factor 1-alpha 1
Gene Name Eef1a1
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. .
GO - Molecular function
  • calmodulin binding : ISO:RGD
  • drug binding : IPI:RGD
  • GTP binding : IEA:UniProtKB-KW
  • GTPase activity : IBA:GO_Central
  • identical protein binding : IPI:RGD
  • kinase binding : ISO:RGD
  • mRNA binding : IDA:RGD
  • protein kinase binding : ISO:RGD
  • translation elongation factor activity : IBA:GO_Central
  • tRNA binding : ISO:RGD
GO - Biological process
  • aging : IEP:RGD
  • cellular response to drug : IEP:RGD
  • cellular response to epidermal growth factor stimulus : ISS:UniProtKB
  • cellular response to nerve growth factor stimulus : IEP:RGD
  • negative regulation of reactive oxygen species biosynthetic process : IMP:RGD
  • positive regulation of cell death : IMP:RGD
  • positive regulation of neuron projection development : IMP:RGD
  • regulation of D-erythro-sphingosine kinase activity : ISS:UniProtKB
  • translation : IBA:GO_Central
  • translational elongation : IBA:GO_Central
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.