Thrombospondin 1 (Q71SA3)

Uniprot ID	Q71SA3
Protein Name	Thrombospondin 1
Gene Name	Thbs1
Species	Rattus norvegicus (Rat)

Signal peptide^(a)	Y	Secretome P^(b)
Function
GO - Molecular function	calcium ion binding : IEA:UniProtKB-UniRule collagen V binding : ISO:RGD extracellular matrix binding : ISO:RGD fibrinogen binding : ISO:RGD fibroblast growth factor binding : ISO:RGD fibronectin binding : ISO:RGD heparin binding : ISO:RGD integrin binding : ISO:RGD laminin binding : ISO:RGD low-density lipoprotein particle binding : ISO:RGD phosphatidylserine binding : ISO:RGD transforming growth factor beta binding : IDA:BHF-UCL
GO - Biological process	activation of MAPK activity : ISO:RGD behavioral response to pain : ISO:RGD blood vessel morphogenesis : ISO:RGD cell adhesion : IEA:InterPro cell cycle arrest : ISO:RGD cell migration : ISO:RGD cellular response to growth factor stimulus : IEP:RGD cellular response to nitric oxide : ISO:RGD cellular response to tumor necrosis factor : IEP:RGD chronic inflammatory response : ISO:RGD endocardial cushion development : ISO:RGD engulfment of apoptotic cell : ISO:RGD growth plate cartilage development : ISO:RGD immune response : ISO:RGD inflammatory response : ISO:RGD negative regulation of angiogenesis : IDA:RGD negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II : ISO:RGD negative regulation of apoptotic process : ISO:RGD negative regulation of blood vessel endothelial cell migration : ISO:RGD negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis : ISO:RGD negative regulation of cell migration involved in sprouting angiogenesis : ISO:RGD negative regulation of cell-matrix adhesion : ISO:RGD negative regulation of cGMP-mediated signaling : ISO:RGD negative regulation of cysteine-type endopeptidase activity involved in apoptotic process : ISO:RGD negative regulation of dendritic cell antigen processing and presentation : ISO:RGD negative regulation of endothelial cell chemotaxis : ISO:RGD negative regulation of endothelial cell migration : ISO:RGD negative regulation of endothelial cell proliferation : ISO:RGD negative regulation of fibrinolysis : ISO:RGD negative regulation of fibroblast growth factor receptor signaling pathway : ISO:RGD negative regulation of interleukin-12 production : ISO:RGD negative regulation of long-chain fatty acid import across plasma membrane : ISO:RGD negative regulation of nitric oxide mediated signal transduction : ISO:RGD negative regulation of plasminogen activation : ISO:RGD negative regulation of sprouting angiogenesis : ISO:RGD outflow tract morphogenesis : ISO:RGD peptide cross-linking : ISO:RGD positive regulation of angiogenesis : ISO:RGD positive regulation of blood coagulation : ISO:RGD positive regulation of blood vessel endothelial cell migration : ISO:RGD positive regulation of cell migration : ISO:RGD positive regulation of cell population proliferation : ISO:RGD positive regulation of cell-substrate adhesion : ISO:RGD positive regulation of chemotaxis : ISO:RGD positive regulation of endothelial cell apoptotic process : ISO:RGD positive regulation of endothelial cell migration : ISO:RGD positive regulation of extrinsic apoptotic signaling pathway via death domain receptors : ISO:RGD positive regulation of fibroblast migration : ISO:RGD positive regulation of macrophage activation : ISO:RGD positive regulation of macrophage chemotaxis : ISO:RGD positive regulation of phosphorylation : ISO:RGD positive regulation of protein kinase B signaling : ISO:RGD positive regulation of reactive oxygen species metabolic process : ISO:RGD positive regulation of smooth muscle cell proliferation : ISO:RGD positive regulation of transforming growth factor beta production : IMP:RGD positive regulation of transforming growth factor beta receptor signaling pathway : ISO:RGD positive regulation of transforming growth factor beta1 production : IDA:BHF-UCL positive regulation of translation : ISO:RGD positive regulation of tumor necrosis factor biosynthetic process : ISO:RGD response to calcium ion : ISO:RGD response to drug : ISO:RGD response to endoplasmic reticulum stress : ISO:RGD response to glucose : ISO:RGD response to magnesium ion : ISO:RGD response to mechanical stimulus : IMP:RGD response to testosterone : IEP:RGD sprouting angiogenesis : ISO:RGD

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^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}