Polypeptide N-acetylgalactosaminyltransferase 2 (Q6PB93)

Uniprot ID Q6PB93
Protein Name Polypeptide N-acetylgalactosaminyltransferase 2
Gene Name Galnt2
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.578
Function Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region (By similarity). .
GO - Molecular function
  • carbohydrate binding : IEA:UniProtKB-KW
  • manganese ion binding : ISS:UniProtKB
  • polypeptide N-acetylgalactosaminyltransferase activity : ISS:UniProtKB
GO - Biological process
  • immunoglobulin biosynthetic process : ISO:MGI
  • O-glycan processing : ISO:MGI
  • protein O-linked glycosylation : ISS:UniProtKB
  • protein O-linked glycosylation via serine : ISO:MGI
  • protein O-linked glycosylation via threonine : ISO:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.