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Q6P793

Triosephosphate isomerase (Q6P793)

Uniprot ID Q6P793
Protein Name Triosephosphate isomerase
Gene Name Tpi1
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. .It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}.
GO - Molecular function
  • isomerase activity : ISO:RGD
  • methylglyoxal synthase activity : ISS:UniProtKB
  • protein homodimerization activity : ISS:UniProtKB
  • triose-phosphate isomerase activity : IDA:RGD
  • ubiquitin protein ligase binding : ISO:RGD
GO - Biological process
  • carbohydrate metabolic process : IDA:RGD
  • gluconeogenesis : IBA:GO_Central
  • glucose metabolic process : ISO:RGD
  • glyceraldehyde-3-phosphate biosynthetic process : ISS:UniProtKB
  • glyceraldehyde-3-phosphate metabolic process : ISO:RGD
  • glycerol catabolic process : IBA:GO_Central
  • glycolytic process : IBA:GO_Central
  • methylglyoxal biosynthetic process : ISS:UniProtKB
  • multicellular organism development : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.