| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Lipoamide dehydrogenase is a component of the glycine cleavage system as well as an E3 component of three alpha-ketoacid dehydrogenase complexes (pyruvate-, alpha-ketoglutarate-, and branched-chain amino acid-dehydrogenase complex). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. In monomeric form may have additional moonlighting function as serine protease (By similarity). Involved in the hyperactivation of spermatazoa during capacitation and in the spermatazoal acrosome reaction (By similarity). . |
| GO - Molecular function |
- dihydrolipoyl dehydrogenase activity : IDA:RGD
- electron transfer activity : IEA:InterPro
- flavin adenine dinucleotide binding : IDA:RGD
- lipoamide binding : IDA:RGD
- NAD binding : IDA:RGD
- pyruvate dehydrogenase (NAD+) activity : IEA:Ensembl
|
| GO - Biological process |
- 2-oxoglutarate metabolic process : IDA:RGD
- acetyl-CoA biosynthetic process from pyruvate : IDA:RGD
- aging : IEP:RGD
- cell redox homeostasis : IEA:InterPro
- dihydrolipoamide metabolic process : IDA:RGD
- gastrulation : ISO:RGD
- histone succinylation : ISS:UniProtKB
- lipoate metabolic process : IDA:RGD
- mitochondrial electron transport, NADH to ubiquinone : ISO:RGD
- proteolysis : ISO:RGD
- regulation of membrane potential : ISO:RGD
- sperm capacitation : ISO:RGD
|