| Signal peptide(a) |
N |
Secretome P(b) |
|
| Function |
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). . |
| GO - Molecular function |
- alpha-catenin binding : ISO:RGD
- cadherin binding : ISO:RGD
- cell adhesion molecule binding : ISO:RGD
- nuclear hormone receptor binding : IBA:GO_Central
- protein kinase binding : IPI:RGD
- protein phosphatase binding : ISO:RGD
- protein-containing complex binding : IPI:RGD
- structural molecule activity : IDA:RGD
- transcription coactivator activity : ISO:RGD
|
| GO - Biological process |
- bundle of His cell-Purkinje myocyte adhesion involved in cell communication : ISO:RGD
- cell adhesion : ISO:RGD
- cell migration : ISO:RGD
- cell-cell adhesion : IDA:RGD
- cellular response to indole-3-methanol : ISO:RGD
- desmosome assembly : ISO:RGD
- detection of mechanical stimulus : ISO:RGD
- negative regulation of blood vessel endothelial cell migration : ISO:RGD
- positive regulation of angiogenesis : ISO:RGD
- positive regulation of cell-matrix adhesion : ISO:RGD
- positive regulation of DNA-binding transcription factor activity : ISO:RGD
- positive regulation of protein import into nucleus : ISO:RGD
- positive regulation of transcription by RNA polymerase II : IBA:GO_Central
- protein localization to plasma membrane : ISO:RGD
- regulation of cell population proliferation : ISO:RGD
- regulation of heart rate by cardiac conduction : ISO:RGD
- regulation of ventricular cardiac muscle cell action potential : ISO:RGD
- skin development : ISO:RGD
|