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Q6IUU3

Sulfhydryl oxidase 1 (Q6IUU3)

Uniprot ID Q6IUU3
Protein Name Sulfhydryl oxidase 1
Gene Name Qsox1
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:11278790). Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (By similarity). .
GO - Molecular function
  • FAD binding : IDA:UniProtKB
  • flavin-linked sulfhydryl oxidase activity : IDA:UniProtKB
  • protein disulfide isomerase activity : ISS:UniProtKB
GO - Biological process
  • cell redox homeostasis : IEA:InterPro
  • extracellular matrix assembly : ISO:RGD
  • negative regulation of macroautophagy : ISO:RGD
  • protein folding : IBA:GO_Central
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.