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Q6IG02

Keratin, type II cytoskeletal 2 epidermal (Q6IG02)

Uniprot ID Q6IG02
Protein Name Keratin, type II cytoskeletal 2 epidermal
Gene Name Krt2
Species Rattus norvegicus (Rat)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b)
Function Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization (By similarity). Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). .
GO - Molecular function
  • cytoskeletal protein binding : ISO:RGD
  • structural constituent of skin epidermis : ISO:RGD
GO - Biological process
  • epidermis development : ISO:RGD
  • intermediate filament organization : ISO:RGD
  • keratinization : ISO:RGD
  • keratinocyte activation : ISO:RGD
  • keratinocyte development : ISO:RGD
  • keratinocyte migration : ISO:RGD
  • keratinocyte proliferation : ISO:RGD
  • peptide cross-linking : ISO:RGD
  • positive regulation of epidermis development : ISS:UniProtKB
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.