Sorbitol dehydrogenase (Q64442)

Uniprot ID Q64442
Protein Name Sorbitol dehydrogenase
Gene Name Sord
Species Mus musculus (Mouse)
Signal peptide(a) N Secretome P(b) 0.597
Function Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. .
GO - Molecular function
  • D-xylulose reductase activity : ISO:MGI
  • identical protein binding : ISO:MGI
  • L-iditol 2-dehydrogenase activity : IDA:MGI
  • NAD binding : ISO:MGI
  • zinc ion binding : ISO:MGI
GO - Biological process
  • flagellated sperm motility : IDA:UniProtKB
  • fructose biosynthetic process : ISO:MGI
  • L-xylitol catabolic process : ISO:MGI
  • L-xylitol metabolic process : ISO:MGI
  • response to cadmium ion : ISO:MGI
  • response to copper ion : ISO:MGI
  • response to drug : IEA:Ensembl
  • response to hormone : ISO:MGI
  • response to nutrient levels : IEA:Ensembl
  • response to osmotic stress : IEA:Ensembl
  • sorbitol catabolic process : ISO:MGI
  • sorbitol metabolic process : IDA:MGI
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.