| Signal peptide(a) |
N |
Secretome P(b) |
0.0 |
| Function |
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom. . |
| GO - Molecular function |
- acetylcholine receptor binding : ISS:BHF-UCL
- calcium channel regulator activity : ISS:BHF-UCL
- calcium ion binding : IDA:RGD
- calcium-dependent protein binding : ISO:RGD
- cell adhesion molecule binding : ISS:BHF-UCL
- neuroligin family protein binding : ISS:BHF-UCL
- protein-containing complex binding : IDA:RGD
- transmembrane signaling receptor activity : ISO:RGD
- type 1 fibroblast growth factor receptor binding : ISO:RGD
|
| GO - Biological process |
- adult behavior : ISS:BHF-UCL
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules : ISO:RGD
- cerebellar granule cell differentiation : ISO:RGD
- chemical synaptic transmission : ISS:BHF-UCL
- circadian rhythm : IEP:RGD
- establishment of protein localization : ISO:RGD
- filopodium assembly : ISO:RGD
- gamma-aminobutyric acid receptor clustering : ISO:RGD
- gephyrin clustering involved in postsynaptic density assembly : ISS:BHF-UCL
- guanylate kinase-associated protein clustering : ISO:RGD
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules : ISO:RGD
- learning : ISS:BHF-UCL
- negative regulation of filopodium assembly : ISO:RGD
- negative regulation of gene expression : ISO:RGD
- neuroligin clustering involved in postsynaptic membrane assembly : ISS:BHF-UCL
- neuromuscular process controlling balance : ISS:BHF-UCL
- neuron cell-cell adhesion : ISO:RGD
- neuron maturation : ISO:RGD
- neuron projection development : ISO:RGD
- neurotransmitter secretion : ISS:BHF-UCL
- NMDA glutamate receptor clustering : ISO:RGD
- positive regulation of ERK1 and ERK2 cascade : ISO:RGD
- positive regulation of excitatory postsynaptic potential : ISS:BHF-UCL
- positive regulation of fibroblast growth factor receptor signaling pathway : ISO:RGD
- positive regulation of gene expression : ISO:RGD
- positive regulation of peptidyl-serine phosphorylation : ISO:RGD
- positive regulation of protein kinase A signaling : ISO:RGD
- positive regulation of protein kinase B signaling : ISO:RGD
- positive regulation of protein kinase C activity : ISO:RGD
- positive regulation of protein localization to plasma membrane : ISO:RGD
- positive regulation of synapse assembly : ISS:BHF-UCL
- positive regulation of synapse maturation : ISS:BHF-UCL
- positive regulation of synaptic transmission, glutamatergic : ISS:BHF-UCL
- postsynaptic density protein 95 clustering : ISS:BHF-UCL
- postsynaptic membrane assembly : ISS:BHF-UCL
- prepulse inhibition : ISS:BHF-UCL
- presynapse assembly : IDA:SynGO
- presynaptic membrane assembly : ISO:RGD
- protein localization to synapse : ISO:RGD
- protein-containing complex assembly involved in synapse maturation : ISO:RGD
- receptor localization to synapse : ISO:RGD
- regulation of AMPA receptor activity : ISO:RGD
- regulation of grooming behavior : ISS:BHF-UCL
- regulation of insulin secretion involved in cellular response to glucose stimulus : ISO:RGD
- regulation of NMDA receptor activity : ISO:RGD
- regulation of postsynaptic density assembly : ISO:RGD
- regulation of postsynaptic specialization assembly : ISO:RGD
- regulation of presynapse assembly : ISO:RGD
- regulation of synaptic vesicle cycle : ISO:RGD
- signal transduction : ISO:RGD
- social behavior : ISO:RGD
- synapse assembly : ISS:BHF-UCL
- synaptic membrane adhesion : ISO:RGD
- synaptic vesicle clustering : ISO:RGD
- trans-synaptic signaling by endocannabinoid : ISO:RGD
- vesicle docking involved in exocytosis : IMP:MGI
- vocal learning : ISO:RGD
- vocalization behavior : ISO:RGD
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