Dystroglycan (Q62165)

Uniprot ID	Q62165
Protein Name	Dystroglycan
Gene Name	Dag1
Species	Mus musculus (Mouse)

Signal peptide^(a)	Y	Secretome P^(b)	0.083
Function	The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also receptor for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity (By similarity). .
GO - Molecular function	actin binding : ISO:MGI alpha-actinin binding : ISO:MGI calcium ion binding : IEA:InterPro dystroglycan binding : IPI:CAFA identical protein binding : ISO:MGI laminin binding : ISO:MGI laminin-1 binding : ISO:MGI SH2 domain binding : ISO:MGI structural constituent of muscle : ISO:MGI tubulin binding : ISO:MGI vinculin binding : ISO:MGI
GO - Biological process	aging : IEA:Ensembl angiogenesis involved in wound healing : IEA:Ensembl axon regeneration : IEA:Ensembl basement membrane organization : IMP:MGI branching involved in salivary gland morphogenesis : IMP:MGI calcium-dependent cell-matrix adhesion : ISO:MGI cellular response to cholesterol : IEA:Ensembl cellular response to mechanical stimulus : ISO:MGI commissural neuron axon guidance : IMP:MGI cytoskeletal anchoring at plasma membrane : ISO:MGI epithelial tube branching involved in lung morphogenesis : IMP:MGI membrane protein ectodomain proteolysis : ISO:MGI microtubule anchoring : ISO:MGI modulation by virus of host morphology or physiology : ISO:MGI morphogenesis of an epithelial sheet : IMP:MGI myelination in peripheral nervous system : IMP:UniProtKB negative regulation of cell migration : ISO:MGI negative regulation of MAPK cascade : ISO:MGI negative regulation of protein kinase B signaling : ISO:MGI nerve maturation : IMP:UniProtKB positive regulation of basement membrane assembly involved in embryonic body morphogenesis : ISO:MGI positive regulation of cell-matrix adhesion : ISO:MGI positive regulation of myelination : ISO:MGI positive regulation of oligodendrocyte differentiation : ISO:MGI positive regulation of protein kinase activity : ISO:MGI regulation of epithelial to mesenchymal transition : ISO:MGI regulation of gastrulation : ISO:MGI response to denervation involved in regulation of muscle adaptation : IEA:Ensembl response to peptide hormone : IEA:Ensembl Schwann cell development : IMP:UniProtKB skeletal muscle tissue regeneration : IEA:Ensembl

Back

^{(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.}
^{(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.}