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Q61409

cGMP-inhibited 3',5'-cyclic phosphodiesterase B (Q61409)

Uniprot ID Q61409
Protein Name cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Gene Name Pde3b
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (1) Interactions
Signal peptide(a) N Secretome P(b) 0.0
Function Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis (By similarity). .
GO - Molecular function
  • 3',5'-cyclic-AMP phosphodiesterase activity : ISO:MGI
  • 3',5'-cyclic-nucleotide phosphodiesterase activity : ISO:MGI
  • cAMP binding : ISO:MGI
  • cGMP-inhibited cyclic-nucleotide phosphodiesterase activity : ISO:MGI
  • drug binding : ISO:MGI
  • metal ion binding : IEA:UniProtKB-KW
  • phosphoprotein binding : ISO:MGI
  • protein kinase B binding : IPI:BHF-UCL
GO - Biological process
  • angiogenesis : IEA:UniProtKB-KW
  • cAMP catabolic process : ISO:MGI
  • cellular response to insulin stimulus : IEP:BHF-UCL
  • endocrine pancreas development : IDA:MGI
  • glucose homeostasis : IDA:MGI
  • negative regulation of angiogenesis : ISS:UniProtKB
  • negative regulation of cell adhesion : ISO:MGI
  • negative regulation of insulin secretion : ISO:MGI
  • negative regulation of lipid catabolic process : ISO:MGI
  • regulation of insulin secretion : IDA:MGI
  • signal transduction : IEA:InterPro
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.