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Q3T1J1

Eukaryotic translation initiation factor 5A-1 (Q3T1J1)

Uniprot ID Q3T1J1
Protein Name Eukaryotic translation initiation factor 5A-1
Gene Name Eif5a
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (1) Interactions
Signal peptide(a) N Secretome P(b)
Function mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF-alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival (By similarity). May play an important role in brain development and function, and in skeletal muscle stem cell differentiation. .
GO - Molecular function
  • protein N-terminus binding : ISO:RGD
  • ribosome binding : IEA:InterPro
  • RNA binding : ISO:RGD
  • translation elongation factor activity : IBA:GO_Central
  • U6 snRNA binding : ISO:RGD
GO - Biological process
  • aging : IEP:RGD
  • apoptotic process : ISO:RGD
  • cellular response to thyroid hormone stimulus : IEP:RGD
  • mRNA export from nucleus : ISO:RGD
  • negative regulation of apoptotic process : IMP:RGD
  • nucleocytoplasmic transport : ISO:RGD
  • positive regulation of apoptotic process : ISO:RGD
  • positive regulation of cardiac muscle cell apoptotic process : IMP:RGD
  • positive regulation of cell population proliferation : ISO:RGD
  • positive regulation of cytosolic calcium ion concentration : IMP:RGD
  • positive regulation of muscle cell differentiation : IMP:RGD
  • positive regulation of reactive oxygen species metabolic process : IMP:RGD
  • positive regulation of translational elongation : IBA:GO_Central
  • positive regulation of translational termination : IEA:InterPro
  • protein export from nucleus : ISO:RGD
  • translational frameshifting : IEA:InterPro
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.