Signal peptide(a) |
N |
Secretome P(b) |
|
Function |
Nucleolar protein that acts as a regulator of RNA polymerase I by connecting RNA polymerase I with enzymes responsible for ribosomal processing and modification (PubMed:12777385, PubMed:26399832). Required for neural crest specification: following monoubiquitination by the BCR(KBTBD8) complex, associates with NOLC1 and acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). . |
GO - Molecular function |
- protein heterodimerization activity : IPI:UniProtKB
- RNA binding : HDA:UniProtKB
- RNA polymerase I core binding : IDA:UniProtKB
- scaffold protein binding : IPI:CAFA
- transporter activity : TAS:ProtInc
|
GO - Biological process |
- neural crest cell development : IMP:UniProtKB
- neural crest formation : IMP:UniProtKB
- regulation of translation : IMP:UniProtKB
- skeletal system development : TAS:ProtInc
|