| Signal peptide(a) |
N |
Secretome P(b) |
0.432 |
| Function |
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. Binds to membranes containing anionic phospholipids via its tail domain. Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes and normal kidney function. In dendritic cells, may control the movement of class II-containing cytoplasmic vesicles along the actin cytoskeleton by connecting them with the actin network via ARL14EP and ARL14. . |
| GO - Molecular function |
- actin filament binding : IDA:UniProtKB
- ATP binding : IEA:UniProtKB-KW
- ATPase activity, coupled : IDA:UniProtKB
- calmodulin binding : IDA:UniProtKB
- microfilament motor activity : TAS:UniProtKB
- motor activity : TAS:ProtInc
- phosphatidylinositol binding : IDA:UniProtKB
|
| GO - Biological process |
- actin filament-based movement : TAS:UniProtKB
- endocytosis : IMP:UniProtKB
- glomerular basement membrane development : ISS:UniProtKB
- glomerular filtration : ISS:UniProtKB
- glomerular visceral epithelial cell development : ISS:UniProtKB
- in utero embryonic development : IEA:Ensembl
- nitrogen compound metabolic process : IEA:Ensembl
- platelet-derived growth factor receptor signaling pathway : IEA:Ensembl
- post-embryonic hemopoiesis : IEA:Ensembl
- vasculogenesis : IEA:Ensembl
|