| Signal peptide(a) |
N |
Secretome P(b) |
0.11 |
| Function |
RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs (PubMed:28625552). As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response (PubMed:21123651). Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs (PubMed:21123651, PubMed:28625552). . |
| GO - Molecular function |
- DNA binding : IDA:UniProtKB
- double-stranded RNA binding : IDA:UniProtKB
- RNA binding : HDA:UniProtKB
|
| GO - Biological process |
- defense response to virus : IEA:UniProtKB-KW
- negative regulation of transcription, DNA-templated : IDA:UniProtKB
- negative regulation of translation : ISS:UniProtKB
- negative regulation of viral genome replication : ISS:UniProtKB
- positive regulation of transcription, DNA-templated : IDA:UniProtKB
- protein phosphorylation : IDA:UniProtKB
- transcription, DNA-templated : IEA:UniProtKB-KW
|