| Signal peptide(a) |
N |
Secretome P(b) |
0.824 |
| Function |
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). . |
| GO - Molecular function |
- cadherin binding : HDA:BHF-UCL
- identical protein binding : IEA:Ensembl
- peroxidase activity : IDA:MGI
- RNA binding : HDA:UniProtKB
- thioredoxin peroxidase activity : IDA:BHF-UCL
|
| GO - Biological process |
- cell population proliferation : TAS:ProtInc
- cell redox homeostasis : IBA:GO_Central
- cellular response to oxidative stress : TAS:Reactome
- erythrocyte homeostasis : IEA:Ensembl
- hydrogen peroxide catabolic process : IDA:BHF-UCL
- leukocyte activation : IBA:GO_Central
- natural killer cell activation : IDA:UniProtKB
- natural killer cell mediated cytotoxicity : IEA:Ensembl
- regulation of NIK/NF-kappaB signaling : IEA:Ensembl
- regulation of stress-activated MAPK cascade : IEA:Ensembl
- removal of superoxide radicals : IBA:GO_Central
- response to oxidative stress : IBA:GO_Central
- retina homeostasis : HEP:UniProtKB
- skeletal system development : TAS:ProtInc
|