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Q06481

Amyloid-like protein 2 (Q06481)

Uniprot ID Q06481
Protein Name Amyloid-like protein 2
Gene Name APLP2
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) N Secretome P(b) 0.302
Function May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5'-GTCACATG-3'(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity). .
GO - Molecular function
  • DNA binding : NAS:UniProtKB
  • heparin binding : IEA:InterPro
  • identical protein binding : IPI:IntAct
  • serine-type endopeptidase inhibitor activity : IEA:UniProtKB-KW
  • transition metal ion binding : IEA:InterPro
GO - Biological process
  • cellular protein metabolic process : TAS:Reactome
  • G protein-coupled receptor signaling pathway : NAS:UniProtKB
  • platelet degranulation : TAS:Reactome
  • post-translational protein modification : TAS:Reactome
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.