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Q05928

Probetacellulin (Q05928)

Uniprot ID Q05928
Protein Name Probetacellulin
Gene Name Btc
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b) 0.189
Function Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. .
GO - Molecular function
  • epidermal growth factor receptor binding : ISO:MGI
  • growth factor activity : ISO:MGI
GO - Biological process
  • epidermal growth factor receptor signaling pathway : ISO:MGI
  • negative regulation of apoptotic process : IDA:MGI
  • positive regulation of cell differentiation : ISO:MGI
  • positive regulation of cell division : IEA:UniProtKB-KW
  • positive regulation of cell proliferation : IGI:MGI
  • positive regulation of fibroblast proliferation : ISO:MGI
  • positive regulation of mitotic nuclear division : ISS:MGI
  • positive regulation of urine volume : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.