| Signal peptide(a) |
Y |
Secretome P(b) |
0.114 |
| Function |
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). . |
| GO - Molecular function |
- activin binding : IDA:UniProtKB
- activin receptor activity, type I : IEA:Ensembl
- ATP binding : IDA:HGNC-UCL
- cadherin binding : IPI:ARUK-UCL
- metal ion binding : IEA:UniProtKB-KW
- peptide hormone binding : NAS:UniProtKB
- protein homodimerization activity : IDA:BHF-UCL
- protein kinase activity : IDA:BHF-UCL
- protein serine/threonine kinase activity : IDA:HGNC-UCL
- protein tyrosine kinase binding : IPI:ARUK-UCL
- SMAD binding : IDA:HGNC-UCL
- transforming growth factor beta binding : IDA:UniProtKB
- transforming growth factor beta receptor activity, type I : IBA:GO_Central
- transmembrane receptor protein serine/threonine kinase activity : NAS:UniProtKB
|
| GO - Biological process |
- activin receptor signaling pathway : IDA:BHF-UCL
- acute inflammatory response : IEA:Ensembl
- angiogenesis : IBA:GO_Central
- atrial septum primum morphogenesis : IMP:BHF-UCL
- atrioventricular valve morphogenesis : ISS:BHF-UCL
- BMP signaling pathway : IDA:BHF-UCL
- BMP signaling pathway involved in heart development : ISS:BHF-UCL
- branching involved in blood vessel morphogenesis : IEA:Ensembl
- cardiac muscle cell fate commitment : IMP:BHF-UCL
- cellular response to BMP stimulus : IMP:BHF-UCL
- cellular response to growth factor stimulus : IBA:GO_Central
- determination of left/right symmetry : IEA:Ensembl
- embryonic heart tube morphogenesis : IMP:BHF-UCL
- endocardial cushion cell fate commitment : IMP:BHF-UCL
- endocardial cushion fusion : ISS:BHF-UCL
- endocardial cushion morphogenesis : ISS:BHF-UCL
- G1/S transition of mitotic cell cycle : IMP:HGNC-UCL
- gastrulation with mouth forming second : IEA:Ensembl
- germ cell development : IEA:Ensembl
- heart development : IBA:GO_Central
- in utero embryonic development : IEA:Ensembl
- mesoderm formation : IEA:Ensembl
- mitral valve morphogenesis : IMP:BHF-UCL
- negative regulation of activin receptor signaling pathway : IMP:HGNC-UCL
- negative regulation of extrinsic apoptotic signaling pathway : IMP:BHF-UCL
- negative regulation of signal transduction : IMP:HGNC-UCL
- neural crest cell migration : IEA:Ensembl
- pathway-restricted SMAD protein phosphorylation : IDA:BHF-UCL
- peptidyl-threonine phosphorylation : IDA:BHF-UCL
- pharyngeal system development : IEA:Ensembl
- positive regulation of bone mineralization : IMP:BHF-UCL
- positive regulation of cell migration : IGI:BHF-UCL
- positive regulation of determination of dorsal identity : IDA:BHF-UCL
- positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation : ISS:BHF-UCL
- positive regulation of osteoblast differentiation : IMP:BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation : IDA:BHF-UCL
- positive regulation of peptidyl-tyrosine phosphorylation : IMP:ARUK-UCL
- positive regulation of transcription by RNA polymerase II : IDA:BHF-UCL
- positive regulation of transcription, DNA-templated : IDA:UniProtKB
- protein phosphorylation : IDA:HGNC-UCL
- regulation of ossification : IMP:UniProtKB
- smooth muscle cell differentiation : IEA:Ensembl
- transforming growth factor beta receptor signaling pathway : IDA:UniProtKB
- ventricular septum morphogenesis : ISS:BHF-UCL
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