| Signal peptide(a) |
N |
Secretome P(b) |
0.365 |
| Function |
Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter. . |
| GO - Molecular function |
- ATP binding : ISO:MGI
- chromatin binding : ISO:MGI
- chromatin DNA binding : ISO:MGI
- core promoter sequence-specific DNA binding : ISS:UniProtKB
- DNA binding : ISO:MGI
- DNA topoisomerase type I activity : IDA:MGI
- double-stranded DNA binding : ISO:MGI
- protein domain specific binding : ISO:MGI
- protein serine/threonine kinase activity : ISO:MGI
- protein-containing complex binding : ISO:MGI
- single-stranded DNA binding : ISO:MGI
- supercoiled DNA binding : ISO:MGI
|
| GO - Biological process |
- chromatin remodeling : ISS:UniProtKB
- chromosome segregation : IBA:GO_Central
- circadian regulation of gene expression : ISS:UniProtKB
- DNA replication : IMP:MGI
- DNA topological change : IDA:MGI
- embryonic cleavage : IMP:MGI
- peptidyl-serine phosphorylation : ISO:MGI
- response to drug : IEA:Ensembl
- rRNA transcription : ISO:MGI
|