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P99029

Peroxiredoxin-5, mitochondrial (P99029)

Uniprot ID P99029
Protein Name Peroxiredoxin-5, mitochondrial
Gene Name Prdx5
Species Mus musculus (Mouse)
Basic Information Experiments (1) Disease (9) Interactions
Signal peptide(a) N Secretome P(b) 0.758
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. .
GO - Molecular function
  • antioxidant activity : ISS:UniProtKB
  • cysteine-type endopeptidase inhibitor activity involved in apoptotic process : ISO:MGI
  • peroxidase activity : ISO:MGI
  • peroxiredoxin activity : ISO:MGI
  • peroxynitrite reductase activity : ISO:MGI
  • protein dimerization activity : ISO:MGI
  • RNA polymerase III regulatory region DNA binding : ISO:MGI
  • signaling receptor binding : ISS:UniProtKB
  • thioredoxin peroxidase activity : ISO:MGI
GO - Biological process
  • cell redox homeostasis : IEA:InterPro
  • cellular response to reactive oxygen species : ISO:MGI
  • hydrogen peroxide catabolic process : ISS:UniProtKB
  • NADPH oxidation : ISO:MGI
  • negative regulation of apoptotic process : ISO:MGI
  • negative regulation of oxidoreductase activity : ISO:MGI
  • negative regulation of transcription by RNA polymerase III : ISO:MGI
  • positive regulation of collagen biosynthetic process : ISO:MGI
  • reactive nitrogen species metabolic process : ISO:MGI
  • regulation of apoptosis involved in tissue homeostasis : ISO:MGI
  • response to oxidative stress : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.