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P98172

Ephrin-B1 (P98172)

Uniprot ID P98172
Protein Name Ephrin-B1
Gene Name EFNB1
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.179
Function Binds to the receptor tyrosine kinases EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). .Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to the receptor tyrosine kinases EPHB3 (preferred), EPHB1 and EPHA1. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity). {ECO:0000250}.
GO - Molecular function
  • ephrin receptor binding : IBA:GO_Central
  • protein tyrosine kinase activity : EXP:Reactome
GO - Biological process
  • axon guidance : IBA:GO_Central
  • cell adhesion : TAS:ProtInc
  • cell-cell signaling : TAS:ProtInc
  • embryonic pattern specification : IEA:Ensembl
  • ephrin receptor signaling pathway : IBA:GO_Central
  • neural crest cell migration : IEA:Ensembl
  • positive regulation of T cell proliferation : IEA:Ensembl
  • T cell costimulation : IEA:Ensembl
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.