| Signal peptide(a) |
Y |
Secretome P(b) |
0.622 |
| Function |
Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates KDR/VEGFR2 and FLT4/VEGFR3 receptors. . |
| GO - Molecular function |
- chemoattractant activity : ISO:MGI
- growth factor activity : IBA:GO_Central
- vascular endothelial growth factor receptor 3 binding : IPI:MGI
|
| GO - Biological process |
- angiogenesis : ISO:MGI
- animal organ morphogenesis : IMP:MGI
- cellular response to leukemia inhibitory factor : IEP:MGI
- induction of positive chemotaxis : ISO:MGI
- morphogenesis of embryonic epithelium : IMP:MGI
- negative regulation of blood pressure : ISO:MGI
- negative regulation of cell proliferation : IDA:MGI
- positive regulation of angiogenesis : IDA:BHF-UCL
- positive regulation of blood vessel endothelial cell migration : ISO:MGI
- positive regulation of cell division : IEA:UniProtKB-KW
- positive regulation of cell proliferation : IMP:MGI
- positive regulation of cell-matrix adhesion : IDA:MGI
- positive regulation of endothelial cell proliferation : IBA:GO_Central
- positive regulation of epithelial cell proliferation : ISO:MGI
- positive regulation of lymphangiogenesis : IDA:BHF-UCL
- positive regulation of mast cell chemotaxis : ISO:MGI
- positive regulation of neuroblast proliferation : ISO:MGI
- positive regulation of peptidyl-tyrosine phosphorylation : IDA:MGI
- positive regulation of protein autophosphorylation : ISO:MGI
- positive regulation of protein secretion : ISO:MGI
- regulation of vascular endothelial growth factor receptor signaling pathway : ISO:MGI
- response to drug : IEA:Ensembl
- response to hypoxia : IBA:GO_Central
- vascular endothelial growth factor receptor signaling pathway : IDA:BHF-UCL
|