Home Proteins Experiments Diseases Interactions Tutorial
Home
/
Proteins
/
P97290

Plasma protease C1 inhibitor (P97290)

Uniprot ID P97290
Protein Name Plasma protease C1 inhibitor
Gene Name Serping1
Species Mus musculus (Mouse)
Basic Information Experiments (6) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.746
Function Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. May inhibit chymotrypsin and kallikrein.
GO - Molecular function
  • serine-type endopeptidase inhibitor activity : IDA:MGI
GO - Biological process
  • blood coagulation : IEA:UniProtKB-KW
  • complement activation, classical pathway : IEA:UniProtKB-KW
  • fibrinolysis : IEA:UniProtKB-KW
  • innate immune response : IEA:UniProtKB-KW
  • negative regulation of complement activation, lectin pathway : ISS:UniProtKB
Back
(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.