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P80254

D-dopachrome decarboxylase (P80254)

Uniprot ID P80254
Protein Name D-dopachrome decarboxylase
Gene Name Ddt
Species Rattus norvegicus (Rat)
Basic Information Experiments (2) Disease (2) Interactions
Signal peptide(a) N Secretome P(b)
Function Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI).
GO - Molecular function
  • cytokine receptor binding : ISO:RGD
  • D-dopachrome decarboxylase activity : IEA:UniProtKB-EC
  • dopachrome isomerase activity : TAS:RGD
  • phenylpyruvate tautomerase activity : ISO:RGD
  • protease binding : ISO:RGD
GO - Biological process
  • inflammatory response : NAS:RGD
  • melanin biosynthetic process : IEA:UniProtKB-KW
  • negative regulation of macrophage chemotaxis : ISO:RGD
  • positive regulation of ERK1 and ERK2 cascade : ISO:RGD
  • positive regulation of inflammatory response : ISO:RGD
  • positive regulation of tumor necrosis factor production : ISO:RGD
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.