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P80162

C-X-C motif chemokine 6 (P80162)

Uniprot ID P80162
Protein Name C-X-C motif chemokine 6
Gene Name CXCL6
Species Homo sapiens (Human)
Basic Information Experiments (1) Disease (0) Interactions
Signal peptide(a) Y Secretome P(b) 0.733
Function Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). .
GO - Molecular function
  • chemokine activity : IDA:UniProtKB
  • heparin binding : IEA:UniProtKB-KW
GO - Biological process
  • antimicrobial humoral immune response mediated by antimicrobial peptide : IDA:UniProtKB
  • cell-cell signaling : TAS:ProtInc
  • cellular response to lipopolysaccharide : IDA:UniProtKB
  • chemokine-mediated signaling pathway : IBA:GO_Central
  • chemotaxis : TAS:ProtInc
  • defense response to bacterium : IEA:UniProtKB-KW
  • G protein-coupled receptor signaling pathway : TAS:Reactome
  • immune response : IBA:GO_Central
  • inflammatory response : IBA:GO_Central
  • leukocyte chemotaxis : IBA:GO_Central
  • leukocyte homeostasis : IEA:Ensembl
  • neutrophil activation : IDA:UniProtKB
  • neutrophil chemotaxis : IDA:UniProtKB
  • regulation of chemokine production : IEA:Ensembl
  • regulation of neutrophil mediated killing of gram-negative bacterium : IEA:Ensembl
  • signal transduction : TAS:ProtInc
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.