| Signal peptide(a) |
N |
Secretome P(b) |
0.282 |
| Function |
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510). Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro). . |
| GO - Molecular function |
- calcium ion binding : IEA:InterPro
- growth factor activity : NAS:UniProtKB
- Notch binding : IPI:UniProtKB
- phospholipid binding : IMP:CAFA
- structural molecule activity : NAS:UniProtKB
|
| GO - Biological process |
- angiogenesis : NAS:UniProtKB
- aorta morphogenesis : ISS:BHF-UCL
- aortic valve morphogenesis : NAS:BHF-UCL
- blood vessel remodeling : IEA:Ensembl
- cardiac neural crest cell development involved in outflow tract morphogenesis : ISS:BHF-UCL
- cardiac right ventricle morphogenesis : ISS:BHF-UCL
- cardiac septum morphogenesis : ISS:BHF-UCL
- cell fate determination : NAS:UniProtKB
- ciliary body morphogenesis : IEA:Ensembl
- distal tubule development : IEA:Ensembl
- endocardial cushion cell development : ISS:BHF-UCL
- endothelial cell differentiation : NAS:UniProtKB
- glomerular visceral epithelial cell development : ISS:UniProtKB
- hemopoiesis : NAS:UniProtKB
- inner ear auditory receptor cell differentiation : IEA:Ensembl
- keratinocyte differentiation : NAS:UniProtKB
- loop of Henle development : IEA:Ensembl
- morphogenesis of an epithelial sheet : IEA:Ensembl
- myoblast differentiation : NAS:UniProtKB
- negative regulation of cell migration : IDA:UniProtKB
- negative regulation of cell-cell adhesion : IDA:UniProtKB
- negative regulation of cell-matrix adhesion : IDA:UniProtKB
- negative regulation of endothelial cell differentiation : IEA:Ensembl
- negative regulation of fat cell differentiation : IEA:Ensembl
- negative regulation of neuron differentiation : IEA:Ensembl
- negative regulation of Notch signaling pathway : IBA:GO_Central
- negative regulation of stem cell differentiation : IMP:UniProtKB
- nephron development : ISS:UniProtKB
- nervous system development : NAS:UniProtKB
- neuronal stem cell population maintenance : IEP:UniProtKB
- Notch signaling involved in heart development : IMP:BHF-UCL
- Notch signaling pathway : IMP:UniProtKB
- positive regulation of cardiac epithelial to mesenchymal transition : ISS:BHF-UCL
- positive regulation of myeloid cell differentiation : IEA:Ensembl
- positive regulation of Notch signaling pathway : ISS:UniProtKB
- positive regulation of osteoblast differentiation : IEA:Ensembl
- positive regulation of transcription by RNA polymerase II : IMP:BHF-UCL
- pulmonary artery morphogenesis : IMP:BHF-UCL
- pulmonary valve morphogenesis : IMP:BHF-UCL
- regulation of cell population proliferation : NAS:UniProtKB
- response to muramyl dipeptide : IEA:Ensembl
- T cell mediated immunity : IMP:UniProtKB
|