| Signal peptide(a) |
Y |
Secretome P(b) |
0.171 |
| Function |
Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 (PubMed:23125415, PubMed:9931005, PubMed:21829356). Binds to integrins ITGAV:ITGB3 and ITGA4:ITGB1. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1 (PubMed:23125415, PubMed:24789099). The soluble form is chemotactic for T-cells and monocytes and not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (PubMed:9024663, PubMed:9177350). . |
| GO - Molecular function |
- CCR chemokine receptor binding : IBA:GO_Central
- chemoattractant activity : IMP:ARUK-UCL
- chemokine activity : IDA:UniProtKB
- CX3C chemokine receptor binding : IDA:UniProtKB
- CXCR1 chemokine receptor binding : IPI:ARUK-UCL
- integrin binding : IDA:UniProtKB
- signaling receptor binding : TAS:UniProtKB
|
| GO - Biological process |
- aging : ISS:ARUK-UCL
- angiogenesis involved in wound healing : IEA:Ensembl
- autocrine signaling : ISS:ARUK-UCL
- cell adhesion : IPI:ARUK-UCL
- cell chemotaxis : IDA:ARUK-UCL
- cell-cell adhesion : ISS:ARUK-UCL
- cell-cell signaling : TAS:ARUK-UCL
- cellular response to interferon-gamma : IBA:GO_Central
- cellular response to interleukin-1 : IBA:GO_Central
- cellular response to tumor necrosis factor : IBA:GO_Central
- chemokine-mediated signaling pathway : IDA:ARUK-UCL
- chemotaxis : IDA:UniProtKB
- cytokine-mediated signaling pathway : TAS:UniProtKB
- defense response : TAS:UniProtKB
- eosinophil chemotaxis : IBA:GO_Central
- G protein-coupled receptor signaling pathway : ISS:ARUK-UCL
- immune response : TAS:UniProtKB
- inflammatory response : IBA:GO_Central
- integrin activation : IMP:UniProtKB
- leukocyte adhesive activation : TAS:UniProtKB
- leukocyte chemotaxis : TAS:UniProtKB
- leukocyte migration involved in inflammatory response : IMP:UniProtKB
- lymphocyte chemotaxis : IBA:GO_Central
- macrophage chemotaxis : IEA:Ensembl
- microglial cell activation : ISS:ARUK-UCL
- microglial cell proliferation : IMP:ARUK-UCL
- monocyte chemotaxis : IBA:GO_Central
- negative regulation of apoptotic process : IMP:ARUK-UCL
- negative regulation of apoptotic signaling pathway : IGI:ARUK-UCL
- negative regulation of cell migration : IDA:BHF-UCL
- negative regulation of cell-substrate adhesion : NAS:ARUK-UCL
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand : IEA:Ensembl
- negative regulation of glutamate receptor signaling pathway : ISS:ARUK-UCL
- negative regulation of hippocampal neuron apoptotic process : IGI:ARUK-UCL
- negative regulation of interleukin-1 alpha production : ISS:ARUK-UCL
- negative regulation of interleukin-1 beta production : TAS:ARUK-UCL
- negative regulation of interleukin-6 production : TAS:ARUK-UCL
- negative regulation of microglial cell activation : ISS:ARUK-UCL
- negative regulation of neuron migration : TAS:ARUK-UCL
- negative regulation of tumor necrosis factor production : TAS:ARUK-UCL
- negative regulation of tumor necrosis factor secretion : IDA:ARUK-UCL
- neuron cellular homeostasis : ISS:ARUK-UCL
- neuron remodeling : TAS:ARUK-UCL
- neutrophil chemotaxis : IBA:GO_Central
- positive chemotaxis : IMP:ARUK-UCL
- positive regulation of actin filament bundle assembly : IGI:ARUK-UCL
- positive regulation of angiogenesis : IEA:Ensembl
- positive regulation of calcium-independent cell-cell adhesion : IDA:UniProtKB
- positive regulation of cell population proliferation : IMP:ARUK-UCL
- positive regulation of cell-matrix adhesion : TAS:ARUK-UCL
- positive regulation of ERK1 and ERK2 cascade : IBA:GO_Central
- positive regulation of GTPase activity : IBA:GO_Central
- positive regulation of I-kappaB kinase/NF-kappaB signaling : ISS:ARUK-UCL
- positive regulation of I-kappaB phosphorylation : IGI:ARUK-UCL
- positive regulation of inflammatory response : IEP:UniProtKB
- positive regulation of MAPK cascade : IGI:ARUK-UCL
- positive regulation of microglial cell migration : IDA:ARUK-UCL
- positive regulation of neuroblast proliferation : ISS:ARUK-UCL
- positive regulation of neuron projection development : ISS:ARUK-UCL
- positive regulation of NF-kappaB transcription factor activity : IGI:ARUK-UCL
- positive regulation of protein kinase B signaling : IGI:ARUK-UCL
- positive regulation of release of sequestered calcium ion into cytosol : IGI:ARUK-UCL
- positive regulation of smooth muscle cell proliferation : ISS:ARUK-UCL
- positive regulation of transcription by RNA polymerase II : ISS:ARUK-UCL
- positive regulation of transforming growth factor beta1 production : IEA:Ensembl
- regulation of lipopolysaccharide-mediated signaling pathway : IDA:ARUK-UCL
- regulation of neurogenesis : TAS:ARUK-UCL
- regulation of synaptic plasticity : TAS:ARUK-UCL
- response to ischemia : ISS:ARUK-UCL
- synapse pruning : TAS:ARUK-UCL
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