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P70699

Lysosomal alpha-glucosidase (P70699)

Uniprot ID P70699
Protein Name Lysosomal alpha-glucosidase
Gene Name Gaa
Species Mus musculus (Mouse)
Basic Information Experiments (2) Disease (3) Interactions
Signal peptide(a) Y Secretome P(b) 0.697
Function Essential for the degradation of glycogen in lysosomes. Has highest activity on alpha-1,4-linked glycosidic linkages, but can also hydrolyze alpha-1,6-linked glucans. .
GO - Molecular function
  • alpha-1,4-glucosidase activity : IDA:MGI
  • carbohydrate binding : ISO:MGI
  • maltose alpha-glucosidase activity : IEA:UniProtKB-EC
  • oligo-1,6-glucosidase activity : ISO:MGI
GO - Biological process
  • cardiac muscle contraction : ISO:MGI
  • diaphragm contraction : IMP:MGI
  • glycogen catabolic process : IMP:MGI
  • glycogen metabolic process : IMP:MGI
  • heart morphogenesis : IMP:MGI
  • locomotory behavior : IMP:MGI
  • lysosome organization : IMP:MGI
  • muscle cell cellular homeostasis : IMP:MGI
  • neuromuscular process controlling balance : IMP:MGI
  • neuromuscular process controlling posture : IMP:MGI
  • regulation of the force of heart contraction : IMP:MGI
  • striated muscle contraction : IMP:MGI
  • tissue development : IMP:MGI
  • vacuolar sequestering : ISO:MGI
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(a) The Signal peptide D-score cutoff for "YES"(having signal peptide) is 0.45.
(b) Non-classically secreted proteins should obtain an NN-score(Neural Networks score) exceeding the normal threshold of 0.5, but not at the same time be predicted to contain a signal peptide.